The Department of Public Health said the cases are associated with the establishment but has not said whether they are connected to each other. Health officials also have not determined whether either person contracted TB at the club. The department said the risk to the general public is low and that it would notify the public if that assessment changes.

Tuberculosis is caused by bacteria that spread through the air. Infectious disease specialist Abraar Karan of Stanford University has noted that crowded spaces with poor ventilation and close contact can increase transmission risk, and that the bacteria may remain airborne after an infected person has left. TB transmission generally involves prolonged exposure to someone with active disease; people with latent TB infection usually do not have symptoms and are less contagious.

UCSF infectious disease specialist Peter Chin-Hong cautioned against treating the two cases as evidence of an outbreak. Contact tracing may include repeat testing because TB can develop slowly, and an initial test may not detect an infection right away.

The Crazy Horse has operated on mid-Market Street next to the Warfield since 1994. San Francisco typically records 60 to 90 active TB cases a year; the city had 68 in 2025, primarily among people born outside the United States.